Can I Take Other Pain Medications While I’m Taking Fioricet for Pain?

You might be able to take other pain medications, like ibuprofen (Advil, Motrin) or naproxen (Aleve), with Fioricet if you need more relief for your headache. These medications work differently to ease pain and they can help lower the amount of Fioricet you need to relieve your symptoms.

Taking less Fioricet means you’re not as likely to experience the dangers or side effects of taking this medication. But don’t take other medications containing acetaminophen (Tylenol). Fioricet already contains acetaminophen, and you might accidentally take too much acetaminophen if you take these other medications and Fioricet together.

This can lead to serious liver damage. Before using other pain medications with Fioricet, speak with your healthcare provider to make sure it’s safe for you to do so. Other pain medications still carry risks that shouldn’t be ignored (e.g., heart risks, kidney problems).

What is FIoricet ?

BUTALBITAL; ACETAMINOPHEN; CAFFEINE (byoo TAL bi tal; a set a MEE noe fen; KAF een) treats tension headaches. It works by reducing pain. It also helps you relax. It is not used to prevent headaches or migraines. It is a combination of a barbiturate, acetaminophen, and caffeine.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Alagesic, Americet, Anolor-300, Arcet, BAC, CAPACET, Dolgic Plus, Esgic, Esgic Plus, Ezol, Fioricet, Geone, Margesic, Medigesic, Orbivan, Pacaps, Phrenilin Forte, Repan, Tenake, Triad, Zebutal

What may interact with this medication?

  • Alcohol or medications that contain alcohol
  • Antidepressants, especially MAOIs like isocarboxazid, phenelzine, tranylcypromine, and selegiline
  • Antihistamines
  • Benzodiazepines
  • Carbamazepine
  • Isoniazid
  • Medications for pain like pentazocine, buprenorphine, butorphanol, nalbuphine, tramadol, and propoxyphene
  • Muscle relaxants
  • Naltrexone
  • Phenobarbital, phenytoin, and fosphenytoin
  • Phenothiazines like perphenazine, thioridazine, chlorpromazine, mesoridazine, fluphenazine, prochlorperazine, promazine, and trifluoperazine
  • Voriconazole

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.


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